5-Amino-1MQ
50 mg (lyophilized)
Purity:
≥99% (HPLC)
5-Amino-1MQ
50 mg (lyophilized)
+ $25 flat-rate shipping · free at $300+ · Interac e-Transfer ·
About this compound
5-Amino-1MQ (5-Amino-1-methylquinolinium) is a small molecule inhibitor of nicotinamide N-methyltransferase (NNMT), a cytosolic enzyme that catalyzes the methylation of nicotinamide using S-adenosylmethionine (SAM). NNMT plays a central role in cellular energy metabolism, adipogenesis, and epigenetic regulation by modulating the methionine cycle and NAD+ biosynthesis pathways. Preclinical research has examined 5-Amino-1MQ for its potential to reduce adipocyte differentiation, improve insulin sensitivity, and attenuate obesity-related metabolic dysfunction through NNMT inhibition. It represents an emerging class of small molecule metabolic modulators under active investigation.
Storage and handling
Store at -20°C lyophilized, away from moisture and UV light. Keep vials sealed until use. Stable for 2+ years in a non-frost-free freezer.
Preclinical research references
Provided for informational context only. All cited studies involve preclinical or in vitro models. Results do not predict human safety or efficacy. These references do not constitute medical claims.
- Mouse models of diet-induced obesity demonstrated that 5-Amino-1MQ administration significantly reduced adipose tissue mass and body weight gain without changes in caloric intake, accompanied by increased energy expenditure and upregulation of brown adipose tissue markers (Kannt et al., 2018)
- In vitro adipocyte differentiation assays showed dose-dependent inhibition of lipid accumulation and downregulation of adipogenic transcription factors (PPARγ, C/EBPα) in 3T3-L1 preadipocyte cultures treated with 5-Amino-1MQ (Roberti et al., 2021)
- Rodent metabolic studies observed improved insulin sensitivity, reduced fasting glucose, and enhanced mitochondrial oxidative capacity in skeletal muscle tissue following NNMT inhibition with 5-Amino-1MQ in high-fat diet models (Neelakantan et al., 2019)
Shipping & returns
1–5 business days, Canada-wide tracked courier, double tamper-proof packaging.
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Every batch independently tested for purity. COA on file and available before purchase.
FAQ — 5-Amino-1MQ
For research use only. Not for human or veterinary administration.