ACTH 1-39
5 mg (lyophilized)
Purity:
≥99% (HPLC)
Cap colour is for illustration purposes only
ACTH 1-39
5 mg (lyophilized)
+ $25 flat-rate shipping · free at $300+ · Interac e-Transfer ·
About this compound
ACTH 1-39 (Adrenocorticotropic Hormone 1-39) is the full-length, biologically active form of adrenocorticotropic hormone, a 39-amino acid peptide produced and secreted by corticotroph cells of the anterior pituitary gland. ACTH is the primary endogenous regulator of adrenal cortex function, stimulating the synthesis and secretion of glucocorticoids — principally cortisol — through binding to the melanocortin 2 receptor (MC2R) on adrenocortical cells. Beyond its classical role in the hypothalamic-pituitary-adrenal (HPA) axis, ACTH 1-39 also exhibits direct effects via MC1R, MC3R, and MC4R subtypes, influencing pigmentation, immune modulation, and central nervous system signaling. Preclinical research has examined ACTH 1-39 as a tool compound for investigating adrenal steroidogenesis, HPA axis dynamics, melanocortin receptor pharmacology, and neuropeptide signaling in animal models.
Storage and handling
Store at -20°C lyophilized, away from moisture and UV light. Keep vials sealed until use. Stable for 2+ years in a non-frost-free freezer.
Preclinical research references
Provided for informational context only. All cited studies involve preclinical or in vitro models. Results do not predict human safety or efficacy. These references do not constitute medical claims.
- Rodent models demonstrated that ACTH 1-39 administration produced dose-dependent stimulation of adrenal cortisol and corticosterone secretion via MC2R-mediated activation of the PKA/StAR steroidogenic pathway, confirming its utility as a reference agonist in adrenal function studies (Mountjoy et al., 1992)
- Animal pharmacokinetic studies characterized the rapid plasma clearance and short half-life of ACTH 1-39, informing pulsatile dosing protocols used to model physiological HPA axis dynamics in stress-response and circadian rhythm research (Dallman et al., 1987)
- Rodent CNS research demonstrated that centrally administered ACTH 1-39 produced melanocortin receptor-mediated effects on grooming behavior, learning paradigms, and autonomic function independent of adrenal stimulation, establishing its value in neuropeptide pharmacology investigations (de Wied et al., 1975)
Shipping & returns
1–5 business days (5–7 for BC, NL and remote areas), Canada-wide tracked courier, double tamper-proof packaging.
All sales final. Damaged or incorrect orders must be reported within 24 hours with photos.
Every batch independently tested for purity. COA on file and available before purchase.
FAQ — ACTH 1-39
For research use only. Not for human or veterinary administration.