AICAR
100 mg (lyophilized)
Purity:
≥99% (HPLC)
AICAR
100 mg (lyophilized)
+ $25 flat-rate shipping · free at $300+ · Interac e-Transfer ·
About this compound
AICAR (5-Aminoimidazole-4-carboxamide ribonucleotide, also known as Acadesine) is a cell-permeable nucleoside analogue and AMP-kinase (AMPK) activator. Upon cellular uptake, AICAR is phosphorylated to ZMP (AICA ribonucleotide monophosphate), a structural mimic of AMP that directly activates AMPK by binding to its regulatory γ subunit. AMPK is a master energy-sensing kinase that coordinates cellular responses to metabolic stress, regulating glucose uptake, fatty acid oxidation, mitochondrial biogenesis, and protein synthesis. AICAR has been extensively used in preclinical research as a pharmacological tool to study AMPK-dependent pathways, particularly in the context of metabolic regulation, exercise mimicry, cardioprotection, and cellular energy homeostasis.
Storage and handling
Store at -20°C lyophilized, away from moisture and UV light. Keep vials sealed until use. Stable for 2+ years in a non-frost-free freezer.
Preclinical research references
Provided for informational context only. All cited studies involve preclinical or in vitro models. Results do not predict human safety or efficacy. These references do not constitute medical claims.
- Rodent exercise studies demonstrated that AICAR administration activated skeletal muscle AMPK and upregulated PGC-1α-dependent gene expression, producing transcriptional adaptations consistent with endurance training in sedentary animals (Narkar et al., 2008)
- Mouse models of cardiac ischemia-reperfusion injury showed that AICAR pretreatment significantly reduced infarct size and cardiomyocyte apoptosis via AMPK-mediated suppression of mTOR and activation of autophagy pathways (Sukhodub et al., 2007)
- Metabolic studies in insulin-resistant rodent models demonstrated that AICAR improved peripheral glucose uptake and insulin sensitivity through AMPK-stimulated GLUT4 translocation in skeletal muscle, independent of insulin receptor signaling (Hayashi et al., 1998)
Shipping & returns
1–5 business days, Canada-wide tracked courier, double tamper-proof packaging.
All sales final. Damaged or incorrect orders must be reported within 24 hours with photos.
Every batch independently tested for purity. COA on file and available before purchase.
FAQ — AICAR
For research use only. Not for human or veterinary administration.