Humanin
10 mg (lyophilized)
Purity:
≥99% (HPLC)
Humanin
10 mg (lyophilized)
+ $25 flat-rate shipping · free at $300+ · Interac e-Transfer ·
Volume pricing
About this compound
Humanin is a 21-amino acid mitochondria-derived peptide (MDP) encoded within the 16S ribosomal RNA gene of the mitochondrial genome. It was first identified in 2001 through its ability to rescue neurons from Alzheimer's disease-related cellular death. As a mitochondria-derived signaling peptide, Humanin interacts with multiple cell surface receptors — including gp130, FPRL1, and IL-27R — and activates downstream pro-survival pathways such as JAK/STAT3, PI3K/Akt, and MAPK. Preclinical research has investigated Humanin for its cytoprotective, anti-apoptotic, and metabolic effects, with studies spanning neurodegeneration, cardiovascular protection, metabolic syndrome, and age-related cellular decline.
Storage and handling
Store at -20°C lyophilized, away from moisture and UV light. Keep vials sealed until use. Stable for 2+ years in a non-frost-free freezer.
Preclinical research references
Provided for informational context only. All cited studies involve preclinical or in vitro models. Results do not predict human safety or efficacy. These references do not constitute medical claims.
- Neuronal protection studies demonstrated that Humanin potently inhibited apoptosis in cortical neurons exposed to amyloid-beta oligomers and other Alzheimer's disease-related insults, suggesting a role in neuronal survival signaling (Hashimoto et al., 2001)
- Rodent models of myocardial ischemia-reperfusion injury showed that Humanin treatment significantly reduced cardiomyocyte apoptosis and infarct size, with associated improvements in cardiac function and reduced oxidative stress markers (Thummasorn et al., 2011)
- Metabolic studies in aged mice demonstrated that Humanin administration improved insulin sensitivity, reduced hepatic lipid accumulation, and attenuated markers of systemic inflammation, implicating NNMT and mitochondrial signaling in age-associated metabolic dysfunction (Muzumdar et al., 2009)
Shipping & returns
1–5 business days, Canada-wide tracked courier, double tamper-proof packaging.
All sales final. Damaged or incorrect orders must be reported within 24 hours with photos.
Every batch independently tested for purity. COA on file and available before purchase.
FAQ — Humanin
For research use only. Not for human or veterinary administration.