P-21
10 mg (lyophilized)
Purity:
≥99% (HPLC)
Cap colour is for illustration purposes only
P-21
10 mg (lyophilized)
+ $25 flat-rate shipping · free at $300+ · Interac e-Transfer ·
About this compound
P-21 is a synthetic tetrapeptide (Thr-Gly-Glu-Ala) derived from the ciliary neurotrophic factor (CNTF) binding interface. It has been studied in preclinical research as a nootropic and neurogenic compound, with proposed mechanisms involving activation of STAT3 signaling and upregulation of brain-derived neurotrophic factor (BDNF) expression in hippocampal and cortical tissue. P-21 is of interest in research contexts examining neuroplasticity, adult neurogenesis, and cognitive function, particularly in models of age-related cognitive decline and Down syndrome-associated neurological deficits. Unlike full-length CNTF, P-21 is a small, blood-brain barrier-permeable peptide suitable as a research tool compound for CNS studies.
Storage and handling
Store at -20°C lyophilized, away from moisture and UV light. Keep vials sealed until use. Stable for 2+ years in a non-frost-free freezer.
Preclinical research references
Provided for informational context only. All cited studies involve preclinical or in vitro models. Results do not predict human safety or efficacy. These references do not constitute medical claims.
- Rodent models of Down syndrome (Ts65Dn mice) demonstrated that chronic P-21 administration significantly improved spatial learning and memory performance in Morris water maze and novel object recognition tasks compared to vehicle-treated trisomic controls, with associated increases in hippocampal BDNF expression (Bhaskaran et al., 2020)
- Mouse studies observed that P-21 treatment upregulated adult neurogenesis markers in the dentate gyrus, including increased BrdU+ and doublecortin-positive cell counts, suggesting enhanced hippocampal progenitor cell proliferation and differentiation (Bhaskaran et al., 2020)
- Aged rodent models demonstrated that P-21 administration attenuated age-associated declines in synaptic plasticity markers and improved performance on hippocampus-dependent behavioral tasks, consistent with BDNF-mediated neuroprotective and pro-cognitive effects (Crenshaw et al., 2019)
Shipping & returns
1–5 business days (5–7 for BC, NL and remote areas), Canada-wide tracked courier, double tamper-proof packaging.
All sales final. Damaged or incorrect orders must be reported within 24 hours with photos.
Every batch independently tested for purity. COA on file and available before purchase.
FAQ — P-21
For research use only. Not for human or veterinary administration.