PNC-27
10 mg (lyophilized)
Purity:
≥99% (HPLC)
Cap colour is for illustration purposes only
PNC-27
10 mg (lyophilized)
+ $25 flat-rate shipping · free at $300+ · Interac e-Transfer ·
About this compound
PNC-27 is a synthetic peptide comprising a p53 activation domain sequence (residues 12–26) fused to a transmembrane-penetrating domain derived from the HDM-2 binding region. It has been studied in preclinical research for its proposed mechanism of selectively inducing membranolysis in cancer cells that aberrantly express HDM-2 (human double minute 2 protein) on their plasma membrane surface — a characteristic not observed in normal, non-cancerous cells. PNC-27 is proposed to interact with membrane-bound HDM-2, triggering pore formation and subsequent necrotic cell death exclusively in tumor cells. Preclinical research has examined PNC-27 across multiple cancer cell line models and animal tumor models as an investigational oncolytic peptide tool compound.
Storage and handling
Store at -20°C lyophilized, away from moisture and UV light. Keep vials sealed until use. Stable for 2+ years in a non-frost-free freezer.
Preclinical research references
Provided for informational context only. All cited studies involve preclinical or in vitro models. Results do not predict human safety or efficacy. These references do not constitute medical claims.
- In vitro studies using human pancreatic cancer cell lines demonstrated that PNC-27 induced rapid membranolysis and cell death selectively in HDM-2-expressing tumor cells, with no cytotoxic effect observed in matched normal pancreatic ductal cells at equivalent concentrations (Bowne et al., 2008)
- Rodent xenograft models showed that PNC-27 administration reduced tumor volume in HDM-2-overexpressing cancer implants, with histological confirmation of necrotic cell death at the tumor site and preserved surrounding normal tissue architecture (Pankova-Kholmyansky et al., 2014)
- Cell line panel studies across breast, melanoma, and leukemia models demonstrated selective cytotoxicity correlating with HDM-2 membrane expression levels, supporting the proposed membrane-targeted mechanism of action and HDM-2 dependency (Kanovsky et al., 2001)
Shipping & returns
1–5 business days (5–7 for BC, NL and remote areas), Canada-wide tracked courier, double tamper-proof packaging.
All sales final. Damaged or incorrect orders must be reported within 24 hours with photos.
Every batch independently tested for purity. COA on file and available before purchase.
FAQ — PNC-27
For research use only. Not for human or veterinary administration.